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排序方式: 共有2127条查询结果,搜索用时 31 毫秒
81.
82.
Elena Turola Salvatore Petta Ester Vanni Fabiola Milosa Luca Valenti Rosina Critelli Luca Miele Livia Maccio Vincenza Calvaruso Anna L. Fracanzani Marcello Bianchini Nazarena Raos Elisabetta Bugianesi Serena Mercorella Marisa Di Giovanni Antonio Craxì Silvia Fargion Antonio Grieco Calogero Cammà Franco Cotelli Erica Villa 《Disease models & mechanisms》2015,8(9):1037-1046
83.
Frequent self‐weighing as part of a constellation of healthy weight control practices in young adults 下载免费PDF全文
84.
Excess body mass index‐ and waist circumference‐years and incident cardiovascular disease: The CARDIA study 下载免费PDF全文
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86.
Dhammika H. M. L. P. Navarathna Erica V. Stein Elizabeth C. Lessey-Morillon Debasis Nayak Gema Martin-Manso David D. Roberts 《PloS one》2015,10(5)
CD47 is a widely expressed receptor that regulates immunity by engaging its counter-receptor SIRPα on phagocytes and its secreted ligand thrombospondin-1. Mice lacking CD47 can exhibit enhanced or impaired host responses to bacterial pathogens, but its role in fungal immunity has not been examined. cd47-/- mice on a C57BL/6 background showed significantly increased morbidity and mortality following Candida albicans infection when compared with wild-type mice. Despite normal fungal colonization at earlier times, cd47-/- mice at four days post-infection had increased colonization of brain and kidneys accompanied by stronger inflammatory reactions. Neutrophil and macrophage numbers were significantly elevated in kidneys and neutrophils in the brains of infected cd47-/- mice. However, no defect in phagocytic activity towards C. albicans was observed in cd47-/- bone-marrow-derived macrophages, and neutrophil and macrophage killing of C. albicans was not impaired. CD47-deficiency did not alter the early humoral immune response to C. albicans. Th1, Th2, and Th17 population of CD4+ T cells were expanded in the spleen, and gene expression profiles of spleen and kidney showed stronger pro-inflammatory signaling in infected cd47-/- mice. The chemoattractant chemokines MIP-2α and MIP-2β were highly expressed in infected spleens of cd47-/- mice. G-CSF, GM-CSF, and the inflammasome component NLRP3 were more highly expressed in infected cd47-/- kidneys than in infected wild-type controls. Circulating pro- (TNF-α, IL-6) and anti-inflammatory cytokines (IL-10) were significantly elevated, but IL-17 was decreased. These data indicate that CD47 plays protective roles against disseminated candidiasis and alters pro-inflammatory and immunosuppressive pathways known to regulate innate and T cell immunity. 相似文献
87.
Gunjan Piya Erica N. Mueller Heather K. Haas Padmaja L. Ghospurkar Timothy M. Wilson Jaime L. Jensen Christopher L. Colbert Stuart J. Haring 《PloS one》2015,10(2)
Maintaining the integrity of the genome requires the high fidelity duplication of the genome and the ability of the cell to recognize and repair DNA lesions. The heterotrimeric single stranded DNA (ssDNA) binding complex Replication Protein A (RPA) is central to multiple DNA processes, which are coordinated by RPA through its ssDNA binding function and through multiple protein-protein interactions. Many RPA interacting proteins have been reported through large genetic and physical screens; however, the number of interactions that have been further characterized is limited. To gain a better understanding of how RPA functions in DNA replication, repair, and cell cycle regulation and to identify other potential functions of RPA, a yeast two hybrid screen was performed using the yeast 70 kDa subunit, Replication Factor A1 (Rfa1), as a bait protein. Analysis of 136 interaction candidates resulted in the identification of 37 potential interacting partners, including the cell cycle regulatory protein and DNA damage clamp loader Rad24. The Rfa1-Rad24 interaction is not dependent on ssDNA binding. However, this interaction appears affected by DNA damage. The regions of both Rfa1 and Rad24 important for this interaction were identified, and the region of Rad24 identified is distinct from the region reported to be important for its interaction with Rfc2 5. This suggests that Rad24-Rfc2-5 (Rad24-RFC) recruitment to DNA damage substrates by RPA occurs, at least partially, through an interaction between the N terminus of Rfa1 and the C terminus of Rad24. The predicted structure and location of the Rad24 C-terminus is consistent with a model in which RPA interacts with a damage substrate, loads Rad24-RFC at the 5’ junction, and then releases the Rad24-RFC complex to allow for proper loading and function of the DNA damage clamp. 相似文献
88.
The primary cilium provides a hub for reception of extracellular chemical and mechanical cues that influence differentiation, proliferation, and polarity, and contributes to cell cycle control. Ciliary length impacts the cilium's ability to coordinate these processes, and length control defects are linked to a number of clinically important developmental disorders. An exciting new study identifies a new mechanism of ciliary regulation based on interactions of CDK5 and the FBW7 tumor suppressor in regulating the degradation of the centrosomal protein NDE1 (Maskey et al, 2015 ). 相似文献
89.
Di Pierro Erica Ghisla Anne Wauters Lucas A. Molinari Ambrogio Martinoli Adriano Gurnell John Tosi Guido 《European Journal of Wildlife Research》2011,57(3):585-595
Space-use patterns of seed predators are strongly affected by spatiotemporal variation in the abundance of different tree
seeds, their major food source. However, most studies have measured relationships between overall food availability and space
use, and there are few cases where effects of different food resources have been explored. We studied the effects of two food
resources, Norway spruce and silver fir seeds, on space and habitat use in red squirrel in a subalpine conifer forest from
2000 to 2006. Fir seeds disperse in the autumn of the year they are produced, spruce the following spring. We estimated spruce
and fir seed availability within individual home ranges and monitored home-range size using radiotelemetry. Males had larger
home ranges than females and the sexes responded differently to variation in food and density. Spruce seed availability negatively
affected home-range and core-area sizes of males in spring–summer. Space use was not affected by fir seed availability. Squirrels
positively selected spruce for foraging and spruce was always preferred over fir. Our results showed that spruce, but not
fir, affected space and habitat use of squirrels, suggesting they do not behaviourally respond to early seed dispersal in
fir. 相似文献
90.